MicroRNA and Cancer
MiRNAs might function as either oncogenes or tumor suppressors under assured conditions. The dysregulated MiRNAs have been shown to mark the hallmarks of cancer, including supporting proliferative signaling, evading growth suppressors, resisting cell death, activating invasion and metastasis, and inducing angiogenesis. MiRNA expression is tightly controlled by different transcription factors, so abnormal expression of MiRNA in cancer could be due to dysregulation of some key transcription factors, such as c-Myc and p53.
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